منابع مشابه
ExMS: data analysis for HX-MS experiments.
A previous paper considered the problems that presently limit the hydrogen exchange-mass spectrometry (HX-MS) method for studying the biophysical and functional properties of proteins. Many of these problems can be overcome by obtaining and analyzing hundreds of sequentially overlapping peptide fragments that cover the protein many times over (Mayne et al. J. Am. Soc. Mass Spectrom. 2011: 10.10...
متن کاملDeuteration distribution estimation with improved sequence coverage for HX/MS experiments
MOTIVATION Time-resolved hydrogen exchange (HX) followed by mass spectrometry (MS) is a key technology for studying protein structure, dynamics and interactions. HX experiments deliver a time-dependent distribution of deuteration levels of peptide sequences of the protein of interest. The robust and complete estimation of this distribution for as many peptide fragments as possible is instrument...
متن کاملLarge Scale Experiments Data Analysis for Estimation of Hydrodynamic Force Coefficients Part 1: Time Domain Analysis
This paper describes various time-domain methods useful for analyzing the experimental data obtained from a circular cylinder force in terms of both wave and current for estimation of the drag and inertia coefficients applicable to the Morison’s equation. An additional approach, weighted least squares method is also introduced. A set of data obtained from experiments on heavily roughened circul...
متن کاملLarge Scale Experiments Data Analysis for Estimation of Hydrodynamic Force Coefficients
This paper describes the various frequency domain methods which may be used to analyze experiments data on the force experienced by a circular cylinder in wave and current to estimate drag and inertia coefficients for use in Morison’s equation. An additional approach, system identification techniques (SIT) is also introduced. A set of data obtained from experiments on heavily roughened circular...
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Metabolic flux analysis (MFA) is a widely used method for quantifying intracellular metabolic fluxes. It works by feeding cells with isotopic labeled nutrients, measuring metabolite isotopic labeling, and computationally interpreting the measured labeling data to estimate flux. Tandem mass-spectrometry (MS/MS) has been shown to be useful for MFA, providing positional isotopic labeling data. Spe...
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ژورنال
عنوان ژورنال: Journal of The American Society for Mass Spectrometry
سال: 2011
ISSN: 1044-0305,1879-1123
DOI: 10.1007/s13361-011-0236-3